Successful re-introduction of recombinant human erythropoietin following antibody induced pure red cell aplasia
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چکیده
منابع مشابه
Pure Red Cell Aplasia Induced by Antibodies against Human Recombinant Erythropoietin
Human recombinant erythropoietin (epoetin) is a very effective and safe biopharmaceutical. However, in 1998 the incidence of pure red cell aplasia (PRCA) induced by antierythropoietin (anti-EPO) antibodies in patients treated with epoetin started to increase. PRCA is a rare condition of non-regenerative anemia which can be associated with a variety of diseases and is in some cases of immunologi...
متن کاملAnti-erythropoietin antibody-mediated pure red cell aplasia after treatment with recombinant erythropoietin products: recommendations for minimization of risk.
Since 1998, there has been a marked increase in incidence of pure red cell aplasia secondary to development of anti-erythropoietin antibodies (Ab+ PRCA) in patients who have chronic kidney disease (CKD) and receive recombinant erythropoietin. The relationship between incidence of Ab+ PRCA and specific erythropoietin products has not been examined rigorously. Manufacturers provided data regardin...
متن کاملMyelodysplastic Syndrome with Erythroid Aplasia following Pure Red Cell Aplasia
Myelodysplastic syndrome (MDS) with erythroid aplasia is a very rare disorder that has not been clearly defined. We experienced a case of pure red cell aplasia (PRCA), which evolved to MDS with erythroid aplasia. A 59-year-old male with transfusion-dependent PRCA was referred to our hospital for an evaluation of newly developed thrombocytopenia. Two years ago, PRCA was diagnosed by the laborato...
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Long-term administration of azathioprine is widely used to prevent rejection in organ transplantation and in the treatment of autoimmune diseases. Bone marrow toxicity is a well-known side-effect of azathioprine. Macrocytosis, with or without megaloblastic erythropoiesis in the bone marrow, and (mild) leukopenia are frequently seen [1-4]. Less common effects are anaemia, thrombocytopenia and pa...
متن کاملDiphenylhydantoin-induced pure red cell aplasia.
Pure red cell aplasia is an uncommon complication of diphenylhydantoin therapy. It has not been reported in Indian literature. Awareness of the entity helps in establishing the cause of anaemia in these patients and alerts the physicians to the need of comprehensive haematological monitoring in these patients. A case of 58-year-old male who developed pure red cell aplasia following three months...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2004
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfh319